Chemokines as mediators of angiogenesis

Borna Mehrad; Michael P. Keane; Robert M. Strieter

doi:10.1160/TH07-01-0040

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 97(05): 755-762
DOI: 10.1160/TH07-01-0040

Theme Issue Article

Schattauer GmbH

Chemokines as mediators of angiogenesis

Borna Mehrad

¹Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA

,

Michael P. Keane

²Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA

,

Robert M. Strieter

¹Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA

› Author Affiliations

Abstract

Summary

Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation. Members of a subgroup of chemokines, the CXC family, also play a critical role in both physiologic and pathologic angiogenesis, including in the context of chronic inflammation, fibrosis, and malignancy.A unique feature of this family of cytokines is that, on the basis of their structure and receptor binding, individual ligands display either angiogenic or angiostatic biological activity in the regulation of angiogenesis. In this review, we summarize the key literature in this growing field.

Keywords

Chemokine - chemokine receptor - angiogenesis - cancer

Full Text

References

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